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Given the increasing prevalence of autism spectrum disorder (ASD), medical professionals’ understanding of the presentation of ASD is essential to ensuring patients with ASD receive high-quality healthcare. Previous studies have found that individuals with ASD have a lower average bone density and higher fracture risk than those without ASD, increasing the likelihood that these patients will seek orthopaedic care. Early coordination with the patient’s family, identification of stressors and coping strategies, and flexibility during the visit are key to promoting a positive medical encounter. Based on a review of the literature, we present a practical guide for orthopaedic providers to better care for pediatric patients with ASD and their families.