Pediatric Musculoskeletal Infection An Update Through the Four Pillars of Clinical Care and Immunothrombotic Similarities With COVID-19

Main Article Content

Stephanie N. Moore-Lotridge, PhD
Breanne H.Y. Gibson, BS
Matthew T. Duvernay, PhD
Jeffrey E. Martus MD
Isaac P. Thomsen MD, MSCI
Jonathan G. Schoenecker, MD, PhD

Abstract

Few conditions in pediatric orthopaedics provoke more apprehension than a child with a musculoskeletal infection (MSKI). In addition to potential for devastating complications, the infectious organisms, technology to diagnose MSKI and pharmacology to treat MSKI evolve continuously. For these reasons, it is essential that pediatric orthopaedic surgeons be up to date on the current and future MSKI practices. In this review, current and potential future practices are systematically reviewed categorized by the four main tasks of the care team treating MSKI: determining 1) that location of the infection 2) is it an infection, and if so, what is the organism 3) how severe is the infection and 4) how to treat the infection. Finally, considering current events, the philosophy and tools highlighted for use in MSKI are paralleled in COVID-19 (SARS-CoV-2).

Article Details

Section
General Orthopedics
Author Biographies

Stephanie N. Moore-Lotridge, PhD, Vanderbilt University Medical Center

Department of Orthopaedics

Breanne H.Y. Gibson, BS, Vanderbilt University

Department of Pharmacology, Graduatre Student

Matthew T. Duvernay, PhD, Vanderbilt University Medical Center

Department of Orthopaedics, Research Assistant Professor

Jeffrey E. Martus MD, Vanderbilt University Medical Center

Department of Orthopaedics

Isaac P. Thomsen MD, MSCI, Vanderbilt University Medical Center

Department of Pediatrics

Vanderbilt Vaccine Research Program

Vanderbilt Institute for Infection, Immunology, and Inflammation

Jonathan G. Schoenecker, MD, PhD, Vanderbilt University Medical Center

Department of Orthopaedics
Department of Pathology, Microbiology, and Immunology

Department of Pediatrics
Department of Pharmacology